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Muscle Paralysis by Rocuronium During Halothane, Enflurane, Isoflurane, and Total Intravenous Anesthesia

Oris, Bart ; Crul, Jan F ; Vandermeersch, Eugène ; Van Aken, Hugo ; Van Egmond, Jan ; Sabbe, Marc B

Anesthesia and analgesia, 1993-09, Vol.77 (3), p.570-573 [Peer Reviewed Journal]

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  • Title:
    Muscle Paralysis by Rocuronium During Halothane, Enflurane, Isoflurane, and Total Intravenous Anesthesia
  • Author: Oris, Bart ; Crul, Jan F ; Vandermeersch, Eugène ; Van Aken, Hugo ; Van Egmond, Jan ; Sabbe, Marc B
  • Subjects: Biological and medical sciences ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Anesthetics. Neuromuscular blocking agents ; Anesthesia, General - methods ; Humans ; Middle Aged ; Rocuronium ; Male ; Androstanols - pharmacology ; Dose-Response Relationship, Drug ; Neuromuscular Nondepolarizing Agents - pharmacology ; Drug Interactions ; Adult ; Female ; Aged ; Muscle Relaxation - drug effects
  • Is Part Of: Anesthesia and analgesia, 1993-09, Vol.77 (3), p.570-573
  • Description: We determined the dose-response relationship, the onset time, the duration, and the recovery time of a rocuronium neuromuscular block under four anesthesia techniques. Patients were equally randomized to four different groups (n = 20) receiving 0.5%–l% halothane, 1.5%–2% enflurane, 1.2%–1.8% isoflurane end-tidal concentration in 34%/66% O2/N2O, or 6.0 mg-kg h propofol without N2O for anesthesia and alfentanil for analgesia. Strength of thumb adduction in response to single and train-of-four stimulation of the ulnar nerve was quantitated. Rocuronium 0.15, 0.2, 0.25, and 0.3 mg/kg were given intravenously. When maximal depression of twitch tension occurred, supplemental doses up to a total of 0.5 mg/kg were given. If required, additional doses of 0.15 mg/kg were given at 25% recovery of control twitch tension. Standard hemodynamics, end-tidal CO2, and anesthetic gas concentrations were monitored continuously. The mean ED50 (SD) was 0.133 (±0.009) mg/kg for the halothane group, 0.118 (±0.012) mg/kg for the enflurane group, 0.069 (±0.026) mg/kg for the isoflurane group, and 0.167 (±0.007) mg/kg for the total intravenous anesthesia (TIVA) group, respectively. There was a statistically significant difference between the halothane and TIVA, and between the enflurane and TIVA groups (P < 0.05). Rocuronium has a short onset time and an intermediate duration of action. The neuromuscular blocking potency and pharmacodynamic profile are moderately influenced by volatile anesthetics.
  • Publisher: Hagerstown, MD: International Anesthesia Research Society
  • Language: English
  • Identifier: ISSN: 0003-2999
    EISSN: 1526-7598
    DOI: 10.1213/00000539-199309000-00024
    PMID: 8368558
    CODEN: AACRAT
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