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Cracking the BAFF code

Schneider, Pascal ; Mackay, Fabienne

Nature reviews. Immunology, 2009-07, Vol.9 (7), p.491-502 [Peer Reviewed Journal]

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Title:
Cracking the BAFF code
Author: Schneider, Pascal ; Mackay, Fabienne
Subjects: B-Cell Maturation Antigen - immunology ; Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - immunology ; Humans ; Toll-Like Receptors - immunology ; Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism ; Transmembrane Activator and CAML Interactor Protein - metabolism ; Signal Transduction - immunology ; Lymphocyte Activation - immunology ; Animals ; B-Cell Activating Factor - metabolism ; B-Cell Maturation Antigen - metabolism ; B-Lymphocyte Subsets - metabolism ; Autoimmunity - immunology ; Immune Tolerance - immunology ; B-Cell Activating Factor - immunology ; B-Lymphocyte Subsets - immunology ; Ligands ; Toll-Like Receptors - metabolism ; Transmembrane Activator and CAML Interactor Protein - immunology ; Autoimmunity ; Physiological aspects ; B cells ; Research ; Tumor necrosis factor ; Risk factors ; Index Medicus
Is Part Of: Nature reviews. Immunology, 2009-07, Vol.9 (7), p.491-502
Description: The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL (a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess of BAFF leads to the development of autoimmune disorders in animal models, and high levels of BAFF have been detected in the serum of patients with various autoimmune conditions. In this Review, we consider the possibility that in mice autoimmunity induced by BAFF is linked to T cell-independent B cell activation rather than to a severe breakdown of B cell tolerance. We also outline the mechanisms of BAFF signalling, the impact of ligand oligomerization on receptor activation and the progress of BAFF-depleting agents in the clinical setting.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1733
EISSN: 1474-1741
DOI: 10.1038/nri2572
PMID: 19521398

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Cracking the BAFF code

Schneider, Pascal ; Mackay, Fabienne

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