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Myocardial infarction with normal coronary arteries: a condition with multiple etiology and variable prognosis

Kardasz, Isabella ; De Caterina, Raffaele

Giornale italiano di cardiologia (2006), 2006-07, Vol.7 (7), p.474-486 [Peer Reviewed Journal]

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Title:
Myocardial infarction with normal coronary arteries: a condition with multiple etiology and variable prognosis
Author: Kardasz, Isabella ; De Caterina, Raffaele
Subjects: Coronary Thrombosis - diagnosis ; Diagnosis, Differential ; Prognosis ; Myocarditis - complications ; Humans ; Coronary Aneurysm - complications ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - diagnosis ; Myocardial Infarction - diagnostic imaging ; Coronary Disease - diagnosis ; Myocarditis - diagnosis ; Thrombophilia - complications ; Coronary Vasospasm - diagnosis ; Coronary Vessels ; Coronary Angiography ; Thrombophilia - diagnosis ; Coronary Artery Disease - diagnosis ; Coronary Vasospasm - complications ; Coronary Artery Disease - complications ; Coronary Disease - complications ; Coronary Thrombosis - complications ; Myocardial Infarction - physiopathology ; Coronary Aneurysm - diagnosis ; Myocardial Infarction - etiology ; Index Medicus
Is Part Of: Giornale italiano di cardiologia (2006), 2006-07, Vol.7 (7), p.474-486
Description: Myocardial infarction with angiographically normal coronary arteries was recognized more than 30 years ago. Since then, various series of patients with such condition have been described, but the etiology and pathogenesis still remain a matter of debate. Evidence exists for a role of coronary vasospasm, thrombosis, embolization and inflammation, per se or combined, in determining the occurrence of myocardial infarction with angiographically normal coronary arteries. Endothelial dysfunction, possibly superimposed to non-angiographically evident atherosclerosis, may be an underlying common feature predisposing to the acute event. Additionally, myocarditis may explain some of these occurrences. Myocardial infarction with normal coronary arteries is therefore likely to be the result of multiple pathogenetic mechanisms. Although most reports emphasize the good prognosis of this condition, in general much better than myocardial infarction with coronary artery disease, prognosis is likely variable according to the underlying mechanism. This review summarizes current knowledge on this condition and examines areas of recent progress.
Publisher: Italy
Language: Italian
Identifier: ISSN: 1827-6806
EISSN: 1972-6481
PMID: 16977787

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Myocardial infarction with normal coronary arteries: a condition with multiple etiology and variable prognosis

Kardasz, Isabella ; De Caterina, Raffaele

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