skip to main content

Hypothermia and the pharmacokinetics and pharmacodynamics of pancuronium in the cat

R D Miller ; S Agoston ; F van der Pol ; L H Booij ; J F Crul ; J Ham

Journal of Pharmacology and Experimental Therapeutics, 1978-11-01, Vol.207 (2), p.532-538 [Peer Reviewed Journal]

No full-text

Citations Cited by
  • Title:
    Hypothermia and the pharmacokinetics and pharmacodynamics of pancuronium in the cat
  • Author: R D Miller ; S Agoston ; F van der Pol ; L H Booij ; J F Crul ; J Ham
  • Subjects: Cats ; Animals ; Kinetics ; Pancuronium - pharmacology ; Hypothermia - metabolism ; Pancuronium - metabolism ; Index Medicus
  • Is Part Of: Journal of Pharmacology and Experimental Therapeutics, 1978-11-01, Vol.207 (2), p.532-538
  • Description: We tested the effect of hypothermia on the pharmacokinetics and pharmacodynamics of pancuronium in the cat. In 14 cats given pancuronium, 120 microgram/kg i.v., we found that neuromuscular block lasted between 2.5 and 3.0 times longer at 29 degrees C (N = 5) than at 34 degrees C (N = 5) or 39 degrees C (N = 4). The apparent plasma elimination half-life was 46 +/- 7 min (S.E.) at 29 degrees C as compared to 21 +/- 2 and 25 +/- 6 min at 34 and 39 degrees C, respectively. The volume of distribution of the central compartment and total volume of distribution at steady state were less at 29 and 34 dgrees C than at 39 degrees C. Total plasma clearance was 4.3 +/- 0.4 ml/kg/min at 29 degrees C and 10.7 +/- 0.9 and 10.9 +/- 1.5 ml/kg/min at 34 and 39 degrees C, respectively. The reduced plasma clearance resulted at least in part from a markedly reduced biliary and urinary excretion of pancuronium at 29 degrees C as compared to 34 and 39 degrees C. In four other cats, the plasma concentration of pancuronium was correlated with depression of twitch tension under steady-state conditions. The ED50 of pancuronium (plasma concentration required for a 50% depression of twitch tension) was 0.035 and 0.073 microgram/ml at 29 and 38 degrees C, respectively. We conclude that a pancuronium neuromuscular block is prolonged at 29 degrees C because of an increased sensitivity of the neuromuscular junction to pancuronium and delayed biliary and urinary excretion.
  • Publisher: United States: American Society for Pharmacology and Experimental Therapeutics
  • Language: English
  • Identifier: ISSN: 0022-3565
    EISSN: 1521-0103
    PMID: 712635
  • Source: © ProQuest LLC All rights reserved

Searching Remote Databases, Please Wait