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Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

Okubo, Yoshiaki ; Mera, Toshiyuki ; Wang, Limei ; Faustman, Denise L

Scientific reports, 2013-11-06, Vol.3 (1), p.3153-3153 [Peer Reviewed Journal]

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Title:
Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2
Author: Okubo, Yoshiaki ; Mera, Toshiyuki ; Wang, Limei ; Faustman, Denise L
Subjects: Tumor necrosis factor receptors ; Graft-versus-host reaction ; Immunoregulation ; Therapeutic applications ; Hypersensitivity ; Clinical trials ; Cytotoxicity ; T cell receptors ; Lymphocytes T ; Cell surface ; Asthma ; CD4 antigen ; Progeny ; Tumor necrosis factor receptor 2 ; Infectious diseases ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Autoimmune diseases ; Surface markers ; Index Medicus
Is Part Of: Scientific reports, 2013-11-06, Vol.3 (1), p.3153-3153
Description: T-regulatory cells (Tregs ) are a rare lymphocyte subtype that shows promise for treating infectious disease, allergy, graft-versus-host disease, autoimmunity, and asthma. Clinical applications of Tregs have not been fully realized because standard methods of expansion ex vivo produce heterogeneous progeny consisting of mixed populations of CD4 + T cells. Heterogeneous progeny are risky for human clinical trials and face significant regulatory hurdles. With the goal of producing homogeneous Tregs , we developed a novel expansion protocol targeting tumor necrosis factor receptors (TNFR) on Tregs . In in vitro studies, a TNFR2 agonist was found superior to standard methods in proliferating human Tregs into a phenotypically homogeneous population consisting of 14 cell surface markers. The TNFR2 agonist-expanded Tregs also were functionally superior in suppressing a key Treg target cell, cytotoxic T-lymphocytes. Targeting the TNFR2 receptor during ex vivo expansion is a new means for producing homogeneous and potent human Tregs for clinical opportunities.
Publisher: London: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep03153
PMID: 24193319

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Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

Okubo, Yoshiaki ; Mera, Toshiyuki ; Wang, Limei ; Faustman, Denise L

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