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Pneumocystis jirovecii pneumonia in non-HIV-infected patients in the era of novel immunosuppressive therapies

Tasaka, Sadatomo ; Tokuda, Hitoshi

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, November 2014, Vol.88(6 Suppl 11), pp.26-39

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  • Title:
    Pneumocystis jirovecii pneumonia in non-HIV-infected patients in the era of novel immunosuppressive therapies
  • Author: Tasaka, Sadatomo ; Tokuda, Hitoshi
  • Is Part Of: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, November 2014, Vol.88(6 Suppl 11), pp.26-39
  • Description: In human immunodeficiency virus (HIV)-infected patients, Pneumocystis jirovecii pneumonia (PCP) is a well-known opportunistic infection, and its management has been established. However, PCP is an emerging threat to immunocompromised patients without HIV infection, such as those receiving novel immunosuppressive therapeutics for malignancy, organ transplantation, or connective tissue diseases. Clinical manifestations of PCP are quite different between patients with and without HIV-infections. In patients without HIV infection, PCP rapidly progresses, is difficult to diagnose correctly, and causes severe respiratory failure with a poor prognosis. High-resolution computed tomography findings are different between PCP patients with HIV infection and those without. These differences in clinical and radiologic features are the result of severe or dysregulated inflammatory responses that are evoked by a relatively small number of Pneumocystis organisms in patients without HIV infection. In recent...
  • Language: English
  • Identifier: ISSN: 0387-5911 ; PMID: 25796923 Version:1

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