skip to main content

Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population ( IL-4 Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma Risk)

Lu, Yu ; Wu, Zhitong ; Peng, Qiliu ; Ma, Liping ; Zhang, Xiaolian ; Zhao, Jiangyang ; Qin, Xue ; Li, Shan Coleman, William B. (Editor)

2014, Vol.9(10), p.e110061 [Peer Reviewed Journal]

Full text available

Citations Cited by
  • Title:
    Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population ( IL-4 Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma Risk)
  • Author: Lu, Yu ; Wu, Zhitong ; Peng, Qiliu ; Ma, Liping ; Zhang, Xiaolian ; Zhao, Jiangyang ; Qin, Xue ; Li, Shan
  • Coleman, William B. (Editor)
  • Subjects: Research Article ; Biology And Life Sciences ; Medicine And Health Sciences
  • Is Part Of: 2014, Vol.9(10), p.e110061
  • Description: Interleukin-4 (IL-4) is best known as an important mediator and modulator of immune and inflammatory responses. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer, and genetic variations in the IL-4 gene may be associated with the risk of hepatitis B virus (HBV)-related HCC. However, few studies have been conducted on their association. ; To clarify the effects of gene polymorphisms on the risk of HBV-related HCC, two common variants, −590C/T (rs2243250) and −33C/T (rs2070874), and their relationship with HBV-related disease risk were investigated in a Chinese population. ; −590C/T and −33C/T polymorphisms were examined in 154 patients with HBV-related HCC, 62 patients with HBV-induced liver cirrhosis (LC), 129 patients with chronic hepatitis B (CHB), and 94 healthy controls, using the polymerase chain reaction-restriction fragment length polymorphism method and DNA sequencing. ; Overall, no significant differences were observed regarding the −590C/T and −33C/T polymorphism genotypes, alleles, or haplotypes between the patient groups and the healthy controls. However, the CC genotypes of −590C/T and −33C/T polymorphisms were observed to be significantly associated with CHB in subgroup analysis in males [CC versus TT (OR: 4.193, 95% CI: 1.094–16.071,  = 0.037; and OR: 3.438, 95% CI: 1.032–11.458,  = 0.044) and CC versus TT+CT (OR: 4.09, 95% CI: 1.08–15.49,  = 0.038; and OR: 3.43, 95% CI: 1.04–11.28,  = 0.042)]. ; These findings suggest that genetic variants in −590C/T and −33C/T polymorphisms may be a risk factor for CHB in Chinese males but not for HBV-related LC or HCC.
  • Language: English
  • Identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0110061

Searching Remote Databases, Please Wait

  • Searching for
  • inscope:(TRAILS-PRINT),scope:(D-01TRAILS_MSU_GFC),scope:(E-01TRAILS_MSU_GFC),primo_central_multiple_fe
  • Show me what you have so far