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Similar Source of Differential Blood mRNAs in Lung Cancer and Pulmonary Inflammatory Diseases: Calls for Improved Strategy for Identifying Cancer-Specific Biomarkers

Hong, Guini ; Chen, Beibei ; Li, Hongdong ; Zhang, Wenjing ; Zheng, Tingting ; Li, Shan ; Shi, Tongwei ; Guo, Zheng

PLoS One, Sep 2014, Vol.9(9), p.e108104 [Peer Reviewed Journal]

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  • Title:
    Similar Source of Differential Blood mRNAs in Lung Cancer and Pulmonary Inflammatory Diseases: Calls for Improved Strategy for Identifying Cancer-Specific Biomarkers
  • Author: Hong, Guini ; Chen, Beibei ; Li, Hongdong ; Zhang, Wenjing ; Zheng, Tingting ; Li, Shan ; Shi, Tongwei ; Guo, Zheng
  • Subjects: United States–Us ; China ; Blood ; Datasets ; Bioinformatics ; Blood ; Blood ; Genes ; Cancer ; Disease ; Lung Cancer ; Life Sciences ; Inflammation ; Genomics ; Blood ; Signatures ; Inflammatory Diseases ; Gene Expression ; Pneumonia
  • Is Part Of: PLoS One, Sep 2014, Vol.9(9), p.e108104
  • Description: Background Many studies try to identify cancer diagnostic biomarkers by comparing peripheral whole blood (PWB) of cancer samples and healthy controls, explicitly or implicitly assuming that such biomarkers are potential candidate biomarkers for distinguishing cancer from nonmalignant inflammation-associated diseases. Methods Multiple PWB gene expression profiles for lung cancer/inflammation-associated pulmonary diseases were used for differential mRNAs identification and comparison and for proportion estimation of PWB cell subtypes. Results The differentially expressed genes (DE genes) between lung cancer/inflammation-associated pulmonary patients and healthy controls were reproducibly identified in different datasets. For these DE genes observed in lung cancer/inflammation-associated pulmonary diseases, more than 90.2% were differentially expressed between myeloid cells and lymphoid cells, with at least 96.8% having consistent directions of regulation (up- or down-regulations) in myeloid...
  • Language: English
  • Identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0108104

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