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A Large Expansion of the HSFY Gene Family in Cattle Shows Dispersion across Yq and Testis-Specific Expression ( HSFY Structure and Expression in Bulls)

Hamilton, Christine K ; Revay, Tamas ; Domander, Robin ; Favetta, Laura A ; King, W. Allan Orban, Laszlo (Editor)

PLoS ONE, 2011, Vol.6(3), p.e17790 [Peer Reviewed Journal]

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  • Title:
    A Large Expansion of the HSFY Gene Family in Cattle Shows Dispersion across Yq and Testis-Specific Expression ( HSFY Structure and Expression in Bulls)
  • Author: Hamilton, Christine K ; Revay, Tamas ; Domander, Robin ; Favetta, Laura A ; King, W. Allan
  • Orban, Laszlo (Editor)
  • Subjects: Research Article ; Biology ; Veterinary Science ; Genetics And Genomics ; Molecular Biology ; Physiology ; Computational Biology
  • Is Part Of: PLoS ONE, 2011, Vol.6(3), p.e17790
  • Description: Heat shock transcription factor, Y-linked ( HSFY ) is a member of the heat shock transcriptional factor (HSF) family that is found in multiple copies on the Y chromosome and conserved in a number of species. Its function still remains unknown but in humans it is thought to play a role in spermatogenesis. Through real time polymerase chain reaction (PCR) analyses we determined that the HSFY family is largely expanded in cattle (∼70 copies) compared with human (2 functional copies, 4 HSFY -similar copies). Unexpectedly, we found that it does not vary among individual bulls as a copy number variant (CNV). Using fluorescence in situ hybridization (FISH) we found that the copies are dispersed along the long arm of the Y chromosome (Yq). HSFY expression in cattle appears restricted to the testis and its mRNA correlates positively with mRNA markers of spermatogonial and spermatocyte cells ( UCHL1 and TRPC2 , respectively) which suggests that HSFY is expressed (at least in part) in early germ cells.
  • Language: English
  • Identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0017790

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