skip to main content

Hemodynamic and thermoregulatory effects of xylazine-ketamine mixture persist even after the anesthetic stage in rats

Picollo, C ; Serra, A.J ; Levy, R.F ; Antonio, E.L ; Santos, L. Dos ; Tucci, P.J.F

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 01 August 2012, Vol.64(4), pp.860-864 [Peer Reviewed Journal]

Full text available

View all versions
Citations Cited by
  • Title:
    Hemodynamic and thermoregulatory effects of xylazine-ketamine mixture persist even after the anesthetic stage in rats
  • Author: Picollo, C ; Serra, A.J ; Levy, R.F ; Antonio, E.L ; Santos, L. Dos ; Tucci, P.J.F
  • Subjects: Veterinary Sciences ; Anestésico ; Cetamina-Xilasina ; Hemodinâmica ; Termorregulação ; Anesthesia ; Hypotension ; Xylazine-Ketamine ; Hemodynamics ; Thermoregulation ; Veterinary Medicine
  • Is Part Of: Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 01 August 2012, Vol.64(4), pp.860-864
  • Description: The xylazine-ketamine mixture (KX) is an anesthetic approach commonly administered to assess cardiovascular function in rodents. This study aimed to examine if the cardiovascular and thermoregulatory effects of KX could persist after the anesthetic state ceased in rats. Male Wistar rats were anesthetized with K (50mg/kg) X (10mg/kg) through the intra-peritoneal route. Hemodynamic and thermoregulatory repercussions were evaluated in animals in awake state, during an anesthetic depth and after complete recovery of anesthetized state. KX was efficient to significantly induce deep anesthesia in all rats after 10min. A complete recovery of anesthetized state was observed only after 210min. Compared with preanesthetic state and control animals that received no drug, KX induced a significant reduction of systolic and diastolic blood pressure at 10min. Hypotension was more prominent at 150min. The heart rate was also significantly reduced after 10 min of KX and the highest magnitude of bradycardia was observed at 30min. In addition, rectal temperature was markedly decreased at 30min of KX and the higher reduction occurred at 150min. The hemodynamic and thermoregulatory effects of KX were maintained even after complete anesthetic recovery.
  • Language: Portuguese
  • Identifier: ISSN: 1678-4162 ; E-ISSN: 1678-4162 ; DOI: 10.1590/S0102-09352012000400011

Searching Remote Databases, Please Wait