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Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?

Friedman, Jacob E Friedman, Jacob E (correspondence author) ; Friedman, Jacob E (record owner)

Diabetes, November 2018, Vol.67(11), pp.2137-2151 [Peer Reviewed Journal]

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  • Title:
    Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?
  • Author: Friedman, Jacob E
  • Friedman, Jacob E (correspondence author) ; Friedman, Jacob E (record owner)
  • Subjects: Animals–Metabolism ; Diabetes Mellitus, Type 2–Physiology ; Fetal Development–Metabolism ; Haplorhini–Metabolism ; Humans–Metabolism ; Mice–Metabolism ; Obesity–Metabolism ; Abridged
  • Is Part Of: Diabetes, November 2018, Vol.67(11), pp.2137-2151
  • Description: Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to move beyond associations to potential causal mechanisms for developmental programming. Evidence across species compellingly demonstrates that maternal obesity, diabetes, and Western-style diets create a long-lasting signature on multiple systems, including infant stem cells, the early immune system, and gut microbiota. Such exposures accelerate adipogenesis, disrupt mitochondrial metabolism, and impair energy sensing, affecting neurodevelopment, liver, pancreas, and skeletal muscle. Attempts to prevent developmental programming have met with very limited success. A challenging level of complexity is involved in how the host genome, metabolome, and microbiome throughout pregnancy...
  • Language: English
  • Identifier: E-ISSN: 1939-327X ; DOI: 10.2337/dbi17-0011

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