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Parkinson's disease-related fatigue: A case definition and recommendations for clinical research.

Kluger, Benzi M ; Herlofson, Karen ; Chou, Kelvin L ; Lou, Jau-Shin ; Goetz, Christopher G ; Lang, Anthony E ; Weintraub, Daniel ; Friedman, Joseph Kluger, Benzi M (correspondence author) ; Kluger, Benzi M (record owner)

Movement disorders : official journal of the Movement Disorder Society, May 2016, Vol.31(5), pp.625-631 [Peer Reviewed Journal]

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  • Title:
    Parkinson's disease-related fatigue: A case definition and recommendations for clinical research.
  • Author: Kluger, Benzi M ; Herlofson, Karen ; Chou, Kelvin L ; Lou, Jau-Shin ; Goetz, Christopher G ; Lang, Anthony E ; Weintraub, Daniel ; Friedman, Joseph
  • Kluger, Benzi M (correspondence author) ; Kluger, Benzi M (record owner)
  • Subjects: Biomedical Research–Standards ; Fatigue–Diagnosis ; Humans–Etiology ; Parkinson Disease–Complications ; Parkinson'S Disease ; Case Definition ; Clinical Research ; Fatigue
  • Is Part Of: Movement disorders : official journal of the Movement Disorder Society, May 2016, Vol.31(5), pp.625-631
  • Description: Byline: Benzi M. Kluger, Karen Herlofson, Kelvin L. Chou, Jau-Shin Lou, Christopher G. Goetz, Anthony E. Lang, Daniel Weintraub, Joseph Friedman ABSTRACT Fatigue is one of the most common and disabling symptoms in Parkinson's disease (PD). Since fatigue was first described as a common feature of PD 20 years ago, little progress has been made in understanding its causes or treatment. Importantly, PD patients attending the 2013 World Parkinson Congress voted fatigue as the leading symptom in need of further research. In response, the Parkinson Disease Foundation and ProjectSpark assembled an international team of experts to create recommendations for clinical research to advance this field. The working group identified several areas in which shared standards would improve research quality and foster progress including terminology, diagnostic criteria, and measurement. Terminology needs to (1) clearly distinguish fatigue from related phenomena (eg, sleepiness, apathy, depression); (2) differentiate subjective fatigue complaints from objective performance fatigability; and (3) specify domains affected by fatigue and causal factors. We propose diagnostic criteria for PD-related fatigue to guide participant selection for clinical trials and add rigor to mechanistic studies. Recommendations are made for measurement of subjective fatigue complaints, performance fatigability, and neurophysiologic changes. We also suggest areas in which future research is needed to address methodological issues and validate or optimize current practices. Many limitations in current PD-related fatigue research may be addressed by improving methodological standards, many of which are already being successfully applied in clinical fatigue research in other medical conditions (eg, cancer, multiple sclerosis). [c] 2016 International Parkinson and Movement Disorder Society Article Note: Relevant conflicts of interest/financial disclosures: K.H. - Allergan, Abbvie, Novartis; J.H.F. - Teva, Auspex, Pfizer, Osmotica; Lundbeck; Acadia; Demos Press; Medscape; D.W. -research funding or support from Michael J. Fox Foundation for Parkinson's Research, National Institutes of Health, Novartis Pharmaceuticals, Department of Veterans Affairs, Avid Radiopharmaceuticals, and Alzheimer's Disease Cooperative Study; honoraria from AbbVie, Biotie, Teva Pharmaceuticals, Otsuka, UCB, Clintrex LLC, and the CHDI Foundation; license fee payments from the University of Pennsylvania for the QUIP and QUIP-RS; royalties from Wolters Kluweland; and fees for legal consultation for lawsuit related to antipsychotic prescribing in a patient with Parkinson's disease. Funding agencies: The Parkinson's Disease Foundation - ProjectSpark Community Choice Research Award.
  • Language: English
  • Identifier: E-ISSN: 1531-8257 ; DOI: 10.1002/mds.26511

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