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Co-detection in the pathogenesis of severe hand-foot-mouth disease

Liu, Li-Juan ; Xu, Hong-Mei ; Li, Xiu-Jun ; Wang, Jun ; Wang, Xian-Jun ; Ding, Shu-Jun ; Tang, Fang ; Wang, Jing ; Zhang, Ying-Jie

Archives of Virology, 2012, Vol.157(11), pp.2219-2222 [Peer Reviewed Journal]

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  • Title:
    Co-detection in the pathogenesis of severe hand-foot-mouth disease
  • Author: Liu, Li-Juan ; Xu, Hong-Mei ; Li, Xiu-Jun ; Wang, Jun ; Wang, Xian-Jun ; Ding, Shu-Jun ; Tang, Fang ; Wang, Jing ; Zhang, Ying-Jie
  • Subjects: Hand-foot-mouth disease ; enterovirus 71 ; co-detection
  • Is Part Of: Archives of Virology, 2012, Vol.157(11), pp.2219-2222
  • Description: It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p  < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.
  • Language: English
  • Identifier: ISSN: 0304-8608 ; E-ISSN: 1432-8798 ; DOI: 10.1007/s00705-012-1396-6

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