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A sunblock based on bioadhesive nanoparticles

Deng, Yang ; Ediriwickrema, Asiri ; Yang, Fan ; Lewis, Julia ; Girardi, Michael ; Saltzman, W. Mark

Nature materials, 2015-09-28, Vol.14 (12), p.1278-1285 [Peer Reviewed Journal]

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  • Title:
    A sunblock based on bioadhesive nanoparticles
  • Author: Deng, Yang ; Ediriwickrema, Asiri ; Yang, Fan ; Lewis, Julia ; Girardi, Michael ; Saltzman, W. Mark
  • Subjects: Nanoparticles ; Animals ; Ultraviolet Rays ; Skin - metabolism ; Sunscreening Agents - metabolism ; Mice ; Sunscreening Agents - pharmacology ; Skin - drug effects ; Index Medicus
  • Is Part Of: Nature materials, 2015-09-28, Vol.14 (12), p.1278-1285
  • Description: The majority of commercial sunblock preparations use organic or inorganic ultraviolet (UV) filters. Despite protecting against cutaneous phototoxicity, direct cellular exposure to UV filters has raised a variety of health concerns. Here, we show that the encapsulation of padimate O (PO)--a model UV filter--in bioadhesive nanoparticles (BNPs) prevents epidermal cellular exposure to UV filters while enhancing UV protection. BNPs are readily suspended in water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or follicular penetration, and their interaction with skin is water resistant yet the particles can be removed via active towel drying. Although the sunblock based on BNPs contained less than 5 wt% of the UV-filter concentration found in commercial standards, the anti-UV effect was comparable when tested in two murine models. Moreover, the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared with a commercial sunscreen formulation.
  • Publisher: England: Springer Science and Business Media LLC
  • Language: English
  • Identifier: ISSN: 1476-4660
    ISSN: 1476-1122
    EISSN: 1476-4660
    DOI: 10.1038/nmat4422
    PMID: 26413985
  • Source: © ProQuest LLC All rights reserved

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