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Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.(Research Article)(low density lipoprotein)(Report)

Misaka, Tomofumi ; Suzuki, Satoshi ; Sakamoto, Nobuo ; Yamaki, Takayoshi ; Sugimoto, Koichi ; Kunii, Hiroyuki ; Nakazato, Kazuhiko ; Saitoh, Shu - Ichi ; Sawamura, Tatsuya ; Ishibashi, Toshiyuki ; Takeishi, Yasuchika

BioMed Research International, Annual, 2014 [Peer Reviewed Journal]

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  • Title:
    Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.(Research Article)(low density lipoprotein)(Report)
  • Author: Misaka, Tomofumi ; Suzuki, Satoshi ; Sakamoto, Nobuo ; Yamaki, Takayoshi ; Sugimoto, Koichi ; Kunii, Hiroyuki ; Nakazato, Kazuhiko ; Saitoh, Shu - Ichi ; Sawamura, Tatsuya ; Ishibashi, Toshiyuki ; Takeishi, Yasuchika
  • Subjects: Acute Coronary Syndrome -- Diagnosis ; Acute Coronary Syndrome -- Genetic Aspects ; Cell Receptors -- Properties
  • Is Part Of: BioMed Research International, Annual, 2014
  • Description: Background. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty- seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results. We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (P < 0.01, for both). The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (P < 0.01, for both). The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (P < 0.01, for both). Receiver operating characteristic curves for ACS detection demonstrated high sensitivity and specificity for the soluble LOX-1 and LOX-1 index with no differences between the Ao and CS. Conclusions. The present study showed that circulating soluble LOX-1 originates from coronary circulation and soluble LOX-1 and LOX-1 index are useful biomarkers for ACS.
  • Language: English
  • Identifier: ISSN: 2314-6133
  • Source: Cengage Learning, Inc.

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