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B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma

Breen, Elizabeth Crabb ; Hussain, Shehnaz K ; Magpantay, Larry ; Jacobson, Lisa P ; Detels, Roger ; Rabkin, Charles S ; Kaslow, Richard A ; Variakojis, Daina ; Bream, Jay H ; Rinaldo, Charles R ; Ambinder, Richard F ; Martinez-Maza, Otoniel

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, July 2011, Vol.20(7), pp.1303-14 [Peer Reviewed Journal]

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  • Title:
    B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma
  • Author: Breen, Elizabeth Crabb ; Hussain, Shehnaz K ; Magpantay, Larry ; Jacobson, Lisa P ; Detels, Roger ; Rabkin, Charles S ; Kaslow, Richard A ; Variakojis, Daina ; Bream, Jay H ; Rinaldo, Charles R ; Ambinder, Richard F ; Martinez-Maza, Otoniel
  • Subjects: Acquired Immunodeficiency Syndrome -- Complications ; B-Lymphocytes -- Immunology ; Biomarkers, Tumor -- Blood ; Cytokines -- Blood ; Lymphoma, AIDS-Related -- Immunology ; Lymphoma, B-Cell -- Immunology
  • Is Part Of: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, July 2011, Vol.20(7), pp.1303-14
  • Description: The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL). Serum levels of B-cell activation-associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), sCD27, sCD30, C-reactive protein (CRP), and immunoglobulin E were determined in 179 NHL cases and HIV+ controls in the Multicenter AIDS Cohort Study, collected at up to 3 time points per subject, 0 to 5 years prior to AIDS-NHL diagnosis. Serum IL6, IL10, CRP, sCD23, sCD27, and sCD30 levels were all significantly elevated in the AIDS-NHL group, when compared with HIV+ controls or with AIDS controls, after adjusting for CD4 T-cell number. Elevated serum levels of B-cell activation-associated molecules were seen to be associated with the development of systemic [non-CNS (central nervous system)] NHL, but not with the development of primary CNS lymphoma. Levels of certain B-cell stimulatory cytokines and molecules associated with immune activation are elevated for several years preceding the diagnosis of systemic AIDS-NHL. This observation is consistent with the hypothesis that chronic B-cell activation contributes to the development of these hematologic malignancies. Marked differences in serum levels of several molecules are seen for several years prediagnosis in those who eventually develop AIDS-NHL. Some of these molecules may serve as candidate biomarkers and provide valuable information to better define the etiology of NHL.
  • Language: English
  • Identifier: E-ISSN: 1538-7755 ; PMID: 21527584 Version:1 ; DOI: 10.1158/1055-9965.EPI-11-0037

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