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Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates

Roberts, Victoria H J ; Pound, Lynley D ; Thorn, Stephanie R ; Gillingham, Melanie B ; Thornburg, Kent L ; Friedman, Jacob E ; Frias, Antonio E ; Grove, Kevin L

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, June 2014, Vol.28(6), pp.2466-77 [Peer Reviewed Journal]

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  • Title:
    Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates
  • Author: Roberts, Victoria H J ; Pound, Lynley D ; Thorn, Stephanie R ; Gillingham, Melanie B ; Thornburg, Kent L ; Friedman, Jacob E ; Frias, Antonio E ; Grove, Kevin L
  • Subjects: Western-Style Diet ; Insulin Resistance ; Pancreas ; Uterine Blood Flow ; Fetal Development -- Drug Effects ; Stilbenes -- Adverse Effects
  • Is Part Of: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, June 2014, Vol.28(6), pp.2466-77
  • Description: Resveratrol has been proposed as a potential therapeutic to improve metabolic health during pregnancy, yet little is known about the fetal effects of this maternal dietary supplement. We hypothesized that when administered to pregnant nonhuman primates (NHPs), resveratrol would increase uterine blood flow and mitigate the harmful consequences of maternal Western-style diet (WSD) consumption. NHPs were fed a WSD (36% fat) supplemented with 0.37% resveratrol throughout pregnancy. Outcomes were compared with cohorts fed WSD alone and control chow (14% fat) to distinguish between WSD and resveratrol-specific effects in these animals. In the early third trimester, uterine blood flow was measured by Doppler ultrasound before fetal delivery and tissue collection. Resveratrol resulted in 30% maternal weight loss and improved glucose tolerance, increased uterine artery volume blood flow, and decreased placental inflammation and liver triglyceride deposition. In addition, fetal pancreatic mass was...
  • Language: English
  • Identifier: E-ISSN: 1530-6860 ; PMID: 24563374 Version:1 ; DOI: 10.1096/fj.13-245472

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