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Copper(I)-Catalyzed Enantioselective Intramolecular Aminotrifluoromethylation of O-Homoallyl Benzimidates

Mou, Xue-Qing ; Rong, Feng-Ming ; Zhang, Heng ; Chen, Gong ; He, Gang

Organic letters, 21 June 2019, Vol.21(12), pp.4657-4661 [Peer Reviewed Journal]

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  • Title:
    Copper(I)-Catalyzed Enantioselective Intramolecular Aminotrifluoromethylation of O-Homoallyl Benzimidates
  • Author: Mou, Xue-Qing ; Rong, Feng-Ming ; Zhang, Heng ; Chen, Gong ; He, Gang
  • Is Part Of: Organic letters, 21 June 2019, Vol.21(12), pp.4657-4661
  • Description: In the present paper, the Cu(I)-catalyzed intramolecular aminotrifluoromethylation of O-homoallyl benzimidates with Togni reagent I was reported. O-Homoallyl benzimidates equipped with terminal alkenes produced chiral 1,3-oxazines with high enantioselectivity in the presence of a chiral BOX ligand, and racemic tetrahydro-1,3-oxazepines were obtained in high yields from internal alkene derivatives with a monoprotected amino acid additive under similar conditions.
  • Language: English
  • Identifier: E-ISSN: 1523-7052 ; PMID: 31184192 Version:1 ; DOI: 10.1021/acs.orglett.9b01552

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