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Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

S Tejpar ; C Li ; C Yu ; R Poon ; H Denys ; R Sciot ; E Van Cutsem ; J J Cassiman ; B A Alman

British Journal of Cancer, 2001, Vol.85(1), p.98 [Peer Reviewed Journal]

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  • Title:
    Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
  • Author: S Tejpar ; C Li ; C Yu ; R Poon ; H Denys ; R Sciot ; E Van Cutsem ; J J Cassiman ; B A Alman
  • Subjects: Regular Article ; Β-Catenin ; Tcf/Lef Transcription Factors ; Aggressive Fibromatosis ; Apc
  • Is Part Of: British Journal of Cancer, 2001, Vol.85(1), p.98
  • Description: Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by β-catenin stabilization in a human neoplastic process. © 2001 Cancer Research Campaign http://www.bjcancer.com
  • Identifier: ISSN: 0007-0920 ; E-ISSN: 1532-1827 ; DOI: 10.1054/bjoc.2001.1857

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