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Immunoglobulin abnormalities and monoclonal gammopathy of undetermined significance in uninfected and HIV-infected men

Breen, Elizabeth Crabb ; Katzmann, Jerry ; Kyle, Robert ; Detels, Roger

Infectious Agents and Cancer, 2010, Vol.5(Suppl 1), p.A38-A38 [Peer Reviewed Journal]

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  • Title:
    Immunoglobulin abnormalities and monoclonal gammopathy of undetermined significance in uninfected and HIV-infected men
  • Author: Breen, Elizabeth Crabb ; Katzmann, Jerry ; Kyle, Robert ; Detels, Roger
  • Subjects: Meeting Abstracts
  • Is Part Of: Infectious Agents and Cancer, 2010, Vol.5(Suppl 1), p.A38-A38
  • Description: Multiple myeloma (MM) is a non-AIDS related malignancy of an immunoglobulin (Ig)-secreting B cell (plasma cell) usually associated with older age. MM is characterized by the presence of a high concentration monoclonal Ig protein in serum, and excretion of free light chains (FLC) in urine. In the years preceding MM diagnosis, a small monoclonal Ig develops that may be detectable upon serum protein electrophoresis, resulting in a premalignant condition known as monoclonal gammopathy of undetermined significance (MGUS). In an individual with MGUS, there may also be abnormal levels of FLC. Increased circulating levels of Ig, other indicators of B cell hyperactivation, and B cell lymphoma are well-recognized features of HIV infection. There have also been several reports of increased prevalence of MGUS and a meta-analysis showing increased risk of MM among HIV-infected (HIV+) individuals. There are, however, little or no longitudinal data on HIV-associated Ig abnormalities, B cell activation, and MGUS. We have initiated a pilot study within the Multicenter AIDS Cohort Study (MACS), a prospective study of untreated and treated HIV infection and AIDS in the United States, to begin to examine Ig abnormalities associated with MGUS in HIV-uninfected (HIV-) and HIV+ homosexual men.
  • Identifier: E-ISSN: 1750-9378 ; DOI: 10.1186/1750-9378-5-S1-A38 ; PMCID: 3002697

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