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Stimulation of the Immune Response During Activation of the Dopaminergic System in Mice with Opposite Types of Behavior

Idova, G. ; Cheido, M. ; Zhukova, E. ; Devoino, L.

Neuroscience and Behavioral Physiology, 2004, Vol.34(4), pp.417-421 [Peer Reviewed Journal]

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  • Title:
    Stimulation of the Immune Response During Activation of the Dopaminergic System in Mice with Opposite Types of Behavior
  • Author: Idova, G. ; Cheido, M. ; Zhukova, E. ; Devoino, L.
  • Subjects: aggressive and submissive behavior ; dopaminergic system ; D1 and D2 dopamine receptors ; neuroimmunomodulation ; immune response
  • Is Part Of: Neuroscience and Behavioral Physiology, 2004, Vol.34(4), pp.417-421
  • Description: Studies reported here demonstrated that activation of the dopaminergic system induces increases in the immune response regardless of the type of behavior in mice (line CBA), i.e., in aggressive mice, submissive mice, and mice lacking experience of victory or defeat (controls). Changes in the activity of the dopaminergic system were induced with SKF-38393, a selective agonist of dopamine D 1 receptors, and with p-chlorophenylalanine (PCPA), which we have previously shown to activate D 2 receptors. In the aggressive form of behavior, which was characterized by strong (compared with controls) immune responses, SKF-38393 and PCPA led to further increases in the immune response. In submissive mice, activation of the dopaminergic system altered the nature of the immune response, with immunostimulation, as in aggression. It is suggested that activation of the dopaminergic system in conditions of defined psychoemotional status fixed by acquisition of opposite types of behavior, induces the formation of a new neurochemical pattern – the dopaminergic set – which led to changes in the nature and intensity of the immune response.
  • Language: English
  • Identifier: ISSN: 0097-0549 ; E-ISSN: 1573-899X ; DOI: 10.1023/B:NEAB.0000018755.99063.05

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