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Amyloid-beta clearance in Alzheimer's disease


Online access

  • Title:
    Amyloid-beta clearance in Alzheimer's disease
  • Subjects: Alzheimer's disease; Alzheimer's disease -- Pathogenesis; Alzheimer's disease -- Molecular aspects; Neurosciences; Electronic books
  • Description: Strong evidence continues to accumulate indicating that amyloid-beta (Aβ) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aβ are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aβ clearance in AD. The topics covered include proteases that degrade Aβ and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
  • Publisher: Place of publication not identified : Frontiers Media SA
  • Creation Date: 2015
  • Format: 1 online resource (111 pages) : illustrations; digital, PDF file(s)..
  • Language: English
  • Institution Zone MMS ID: 991003053226803381$$I01TRAILS_CARROLL
  • Network Zone MMS ID: 9911536730203366
  • Source: 01TRAILS ALMA

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