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Efficacy and safety of lacosamide as first add-on or later adjunctive treatment for uncontrolled partial-onset seizures: A multicentre open-label trial

Zadeh, Wendy Waldman ; Escartin, Antonio ; Byrnes, William ; Tennigkeit, Frank ; Borghs, Simon ; Li, Ting ; Dedeken, Peter ; De Backer, Marc

Seizure (London, England), 2015, Vol.31, p.72-79 [Peer Reviewed Journal]

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Title:
Efficacy and safety of lacosamide as first add-on or later adjunctive treatment for uncontrolled partial-onset seizures: A multicentre open-label trial
Author: Zadeh, Wendy Waldman ; Escartin, Antonio ; Byrnes, William ; Tennigkeit, Frank ; Borghs, Simon ; Li, Ting ; Dedeken, Peter ; De Backer, Marc
Subjects: Neurology ; Focal epilepsy ; Seizure freedom ; Lacosamide ; Quality of life ; Prospective Studies ; Humans ; Middle Aged ; Seizures - drug therapy ; Anticonvulsants - therapeutic use ; Male ; Treatment Outcome ; Young Adult ; Anticonvulsants - adverse effects ; Acetamides - therapeutic use ; Adolescent ; Acetamides - adverse effects ; Quality of Life ; Adult ; Female ; Aged ; Drug Therapy, Combination ; Cohort Studies ; Clinical trials ; Care and treatment ; Seizures (Medicine) ; Index Medicus
Is Part Of: Seizure (London, England), 2015, Vol.31, p.72-79
Description: Highlights • Lacosamide 300–400 mg/day was efficacious as a first or later add-on for POS. • 37.5% of patients taking lacosamide as first add-on were seizure-free at 12 weeks. • 14.9% of patients taking lacosamide as later add-on were seizure-free at 12 weeks. • Both patient groups reported improvements from Baseline in quality of life outcomes. • Lacosamide was well tolerated, with a good tolerability profile as a first add-on.
Publisher: England: Elsevier Ltd
Language: English
Identifier: ISSN: 1059-1311
EISSN: 1532-2688
DOI: 10.1016/j.seizure.2015.07.001
PMID: 26362380

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Efficacy and safety of lacosamide as first add-on or later adjunctive treatment for uncontrolled partial-onset seizures: A multicentre open-label trial

Zadeh, Wendy Waldman ; Escartin, Antonio ; Byrnes, William ; Tennigkeit, Frank ; Borghs, Simon ; Li, Ting ; Dedeken, Peter ; De Backer, Marc

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