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Effects of combination therapy with a luteinizing hormone-releasing hormone agonist and chlormadinone acetate on rat prostate weight and plasma testosterone levels

Gotanda, K ; Shinbo, A ; Okada, M ; Nakano, Y ; Kobayashi, H ; Sasaki, T ; Hagiwara, M ; Akaza, H

Prostate cancer and prostatic diseases, 2003, Vol.6(1), pp.66-72 [Peer Reviewed Journal]

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  • Title:
    Effects of combination therapy with a luteinizing hormone-releasing hormone agonist and chlormadinone acetate on rat prostate weight and plasma testosterone levels
  • Author: Gotanda, K ; Shinbo, A ; Okada, M ; Nakano, Y ; Kobayashi, H ; Sasaki, T ; Hagiwara, M ; Akaza, H
  • Subjects: Androgen Antagonists -- Pharmacology ; Antineoplastic Agents, Hormonal -- Pharmacology ; Chlormadinone Acetate -- Pharmacology ; Leuprolide -- Pharmacology ; Prostate -- Drug Effects
  • Is Part Of: Prostate cancer and prostatic diseases, 2003, Vol.6(1), pp.66-72
  • Description: We investigated whether the combination of chlormadinone acetate (CMA) and a luteinizing hormone releasing hormone (LH-RH) agonist, leuprorelin acetate (leuprorelin), more markedly decreased ventral prostate and seminal vesicle weights and plasma sex hormone levels in male rats. Four weeks after administration of 0.28, 0.84 or 2.8 mg/kg of leuprorelin, ventral prostate weights significantly decreased (53.8, 54.4 and 64.1%) and the plasma testosterone levels significantly lowered, but not dose-dependently. After repetitive administrations of 3 and 30 mg/kg/day of CMA, the rates of ventral prostatic atrophy were 37.1 and 65.9%, respectively. Although there was no change in the plasma testosterone level at 3 mg/kg, 30 mg/kg of CMA significantly decreased the level. A combination of leuprorelin (0.28 mg/kg) and CMA (3 or 30 mg/kg) more potently induced ventral prostatic and seminal vesicle atrophy than leuprorelin alone. Furthermore, a combination of leuprorelin and CMA (30 mg/kg) more markedly...
  • Language: English
  • Identifier: ISSN: 1365-7852 ; PMID: 12664069 Version:1

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