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Heteroresistance of Cryptococcus gattii to fluconazole

Varma, A ; Kwon-Chung, K J

Antimicrobial agents and chemotherapy, June 2010, Vol.54(6), pp.2303-11 [Peer Reviewed Journal]

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  • Title:
    Heteroresistance of Cryptococcus gattii to fluconazole
  • Author: Varma, A ; Kwon-Chung, K J
  • Subjects: Antifungal Agents -- Pharmacology ; Cryptococcus Gattii -- Drug Effects ; Fluconazole -- Pharmacology
  • Is Part Of: Antimicrobial agents and chemotherapy, June 2010, Vol.54(6), pp.2303-11
  • Description: We analyzed 71 clinical and environmental Cryptococcus gattii strains that had been isolated before or after the advent of azole antifungals to determine their level of heteroresistance to fluconazole (LHF). All strains of C. gattii manifested heteroresistance, with LHFs that ranged between 4 microg/ml and 32 microg/ml. A considerably higher proportion of the C. gattii strains (86%) than Cryptococcus neoformans strains (46%) exhibited LHFs that were > or =16 microg/ml. No significant correlation was observed between the molecular type or serotypes of strains and their respective LHF. The strains which expressed a higher LHF were also more resistant to xenobiotics than the strains with a low LHF, and the level of resistance to xenobiotics was significantly higher than that reported for C. neoformans. The heteroresistant subpopulation, whose level of drug resistance had been raised in a stepwise manner to 64 microg/ml, reverted to the original LHF upon daily transfers in drug-free medium....
  • Language: English
  • Identifier: E-ISSN: 1098-6596 ; PMID: 20385871 Version:1 ; DOI: 10.1128/AAC.00153-10

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