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Low serum vitamin D is associated with high risk of diabetes in Korean adults.

Choi, Han Seok ; Kim, Kyoung-Ah ; Lim, Chi-Yeon ; Rhee, Sang Youl ; Hwang, You-Cheol ; Kim, Kyoung Min ; Kim, Kwang Joon ; Rhee, Yumie ; Lim, Sung-Kil Choi, Han Seok (correspondence author) ; Choi, Han Seok (record owner)

The Journal of nutrition, August 2011, Vol.141(8), pp.1524-1528 [Peer Reviewed Journal]

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  • Title:
    Low serum vitamin D is associated with high risk of diabetes in Korean adults.
  • Author: Choi, Han Seok ; Kim, Kyoung-Ah ; Lim, Chi-Yeon ; Rhee, Sang Youl ; Hwang, You-Cheol ; Kim, Kyoung Min ; Kim, Kwang Joon ; Rhee, Yumie ; Lim, Sung-Kil
  • Choi, Han Seok (correspondence author) ; Choi, Han Seok (record owner)
  • Subjects: Adult–Blood ; Cross-Sectional Studies–Blood ; Diabetes Mellitus–Blood ; Female–Blood ; Humans–Blood ; Insulin Resistance–Blood ; Male–Blood ; Middle Aged–Blood ; Republic of Korea–Blood ; Risk Factors–Blood ; Vitamin D–Blood ; Vitamin D
  • Is Part Of: The Journal of nutrition, August 2011, Vol.141(8), pp.1524-1528
  • Description: Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose [greater than or equal to] 7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration [greater than or equal to] 75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations <25, 25 to <50, and 50 to <75 nmol/L, respectively, after multiple adjustments (P-trend < 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR ([beta] = -0.061 ; P = 0.001) and positively associated with QUICKI ([beta] = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese. J. Nutr. 141: 1524-1528, 2011. doi: 10.3945/jn.111.139121.
  • Language: English
  • Identifier: E-ISSN: 1541-6100 ; DOI: 10.3945/jn.111.139121

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