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A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery.

Liu, Harrison ; Chen, Steven ; Huang, Kevin ; Kim, Jeffrey ; Mo, Han ; Iovine, Raffael ; Gendre, Julie ; Pascal, Pauline ; Li, Qiang ; Sun, Yaping ; Dong, Zhiqiang ; Arkin, Michelle ; Guo, Su ; Huang, Bo Liu, Harrison (correspondence author) ; Liu, Harrison (record owner)

PloS one, 2016, Vol.11(10), p.e0164645 [Peer Reviewed Journal]

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Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis.

Lee, Hyokyeong ; Moody-Davis, Asher ; Saha, Utsab ; Suzuki, Brian M ; Asarnow, Daniel ; Chen, Steven ; Arkin, Michelle ; Caffrey, Conor R ; Singh, Rahul Lee, Hyokyeong (correspondence author) ; Lee, Hyokyeong (record owner)

BMC genomics, 2012, Vol.13 Suppl 1, p.S4 [Peer Reviewed Journal]

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.

Debnath, Anjan ; Parsonage, Derek ; Andrade, Rosa M ; He, Chen ; Cobo, Eduardo R ; Hirata, Ken ; Chen, Steven ; García-Rivera, Guillermina ; Orozco, Esther ; Martínez, Máximo B ; Gunatilleke, Shamila S ; Barrios, Amy M ; Arkin, Michelle R ; Poole, Leslie B ; Mckerrow, James H ; Reed, Sharon L Debnath, Anjan (correspondence author) ; Debnath, Anjan (record owner)

Nature medicine, June 2012, Vol.18(6), pp.956-960 [Peer Reviewed Journal]

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4
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Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.

Engel, Juan C ; Ang, Kenny K H ; Chen, Steven ; Arkin, Michelle R ; Mckerrow, James H ; Doyle, Patricia S Engel, Juan C (correspondence author) ; Engel, Juan C (record owner)

Antimicrobial agents and chemotherapy, August 2010, Vol.54(8), pp.3326-3334 [Peer Reviewed Journal]

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5
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Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development.

El-Sakkary, Nelly ; Chen, Steven ; Arkin, Michelle R ; Caffrey, Conor R ; Ribeiro, Paula El-Sakkary, Nelly (correspondence author) ; El-Sakkary, Nelly (record owner)

Disease models & mechanisms, July 30, 2018, Vol.11(7) [Peer Reviewed Journal]

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6
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Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

Gunatilleke, Shamila ; Calvet, Claudia ; Johnston, Jonathan ; Chen, Chiung-Kuang ; Erenburg, Grigori ; Gut, Jiri ; Engel, Juan ; Ang, Kenny ; Mulvaney, Joseph ; Chen, Steven ; Arkin, Michelle ; Mckerrow, James ; Podust, Larissa

PLoS Neglected Tropical Diseases, Jul 2012, p.e1736 [Peer Reviewed Journal]

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7
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Lead identification to clinical candidate selection: drugs for Chagas disease.

Neitz, R Jeffrey ; Chen, Steven ; Supek, Frantisek ; Yeh, Vince ; Kellar, Danielle ; Gut, Jiri ; Bryant, Clifford ; Gallardo-Godoy, Alejandra ; Molteni, Valentina ; Roach, Steven L ; Khare, Shilpi ; Stinson, Monique ; Chatterjee, Arnab K ; Robertson, Stephanie ; Renslo, Adam R ; Arkin, Michelle ; Glynne, Richard ; Mckerrow, James ; Siqueira-Neto, Jair L Neitz, R Jeffrey (correspondence author) ; Neitz, R Jeffrey (record owner)

Journal of biomolecular screening, January 2015, Vol.20(1), pp.101-111 [Peer Reviewed Journal]

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.

Gallagher, Ciara M ; Garri, Carolina ; Cain, Erica L ; Ang, Kenny Kean-Hooi ; Wilson, Christopher G ; Chen, Steven ; Hearn, Brian R ; Jaishankar, Priyadarshini ; Aranda-Diaz, Andres ; Arkin, Michelle R ; Renslo, Adam R ; Walter, Peter Gallagher, Ciara M (correspondence author) ; Gallagher, Ciara M (record owner)

eLife, July 20, 2016, Vol.5 [Peer Reviewed Journal]

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UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area.

Arkin, Michelle R ; Ang, Kenny K H ; Chen, Steven ; Davies, Julia ; Merron, Connie ; Tang, Yinyan ; Wilson, Christopher G M ; Renslo, Adam R Arkin, Michelle R (correspondence author) ; Arkin, Michelle R (record owner)

Combinatorial chemistry & high throughput screening, May 2014, Vol.17(4), pp.333-342 [Peer Reviewed Journal]

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