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1
Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide
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Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide

Schneider, Gisbert ; Reker, Daniel ; Chen, Tao ; Hauenstein, Kurt ; Schneider, Petra ; Altmann, KarlHeinz

Angewandte Chemie (International ed.), 2016-09-26, Vol.55 (40), p.12408-12411 [Peer Reviewed Journal]

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2
Beta-caryophyllene is a dietary cannabinoid
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Beta-caryophyllene is a dietary cannabinoid

Jürg Gertsch ; Marco Leonti ; Stefan Raduner ; Ildiko Racz ; Jian-Zhong Chen ; Xiang-Qun Xie ; Karl-Heinz Altmann ; Meliha Karsak ; Andreas Zimmer

Proceedings of the National Academy of Sciences - PNAS, 2008-07-01, Vol.105 (26), p.9099-9104 [Peer Reviewed Journal]

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3
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
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A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

Andrea E. Prota ; Katja Bargsten ; J. Fernando Diaz ; May Marsh ; Carmen Cuevas ; Marc Liniger ; Christian Neuhaus ; Jose M. Andreu ; Karl-Heinz Altmann ; Michel O. Steinmetz

Proceedings of the National Academy of Sciences - PNAS, 2014-08-11, Vol.111 (38), p.13817-13821

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4
Multidimensional Design of Anticancer Peptides
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Multidimensional Design of Anticancer Peptides

Lin, Yen‐Chu ; Lim, Yi Fan ; Russo, Erica ; Schneider, Petra ; Bolliger, Lea ; Edenharter, Adriana ; Altmann, KarlHeinz ; Halin, Cornelia ; Hiss, Jan A ; Schneider, Gisbert

Angewandte Chemie (International ed.), 2015-08-24, Vol.54 (35), p.10370-10374 [Peer Reviewed Journal]

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5
Synthesis and Biological Activity of 7,8,9‐Trideoxy‐ and 7R DesTHP‐Peloruside A
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Synthesis and Biological Activity of 7,8,9‐Trideoxy‐ and 7R DesTHP‐Peloruside A

Wullschleger, Christoph W ; Gertsch, Jürg ; Altmann, KarlHeinz

Chemistry : a European journal, 2013-09-23, Vol.19 (39), p.13105-13111

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6
Fragment‐Based De Novo Design Reveals a Small‐Molecule Inhibitor of Helicobacter Pylori HtrA
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Fragment‐Based De Novo Design Reveals a Small‐Molecule Inhibitor of Helicobacter Pylori HtrA

Perna, Anna M ; Rodrigues, Tiago ; Schmidt, Thomas P ; Böhm, Manja ; Stutz, Katharina ; Reker, Daniel ; Pfeiffer, Bernhard ; Altmann, KarlHeinz ; Backert, Steffen ; Wessler, Silja ; Schneider, Gisbert

Angewandte Chemie, 2015-08-24, Vol.127 (35), p.10382-10386 [Peer Reviewed Journal]

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7
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands
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Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

Balaguer, Francisco de Asís ; Mühlethaler, Tobias ; Estévez-Gallego, Juan ; Calvo, Enrique ; Giménez-Abián, Juan Francisco ; Risinger, April L ; Sorensen, Erik J ; Vanderwal, Christopher D ; Altmann, Karl-Heinz ; Mooberry, Susan L ; Steinmetz, Michel O ; Oliva, María Ángela ; Prota, Andrea E ; Díaz, J Fernando

International journal of molecular sciences, 2019-03-20, Vol.20 (6), p.1392 [Peer Reviewed Journal]

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8
Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives
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Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives

Altmann, Karl-Heinz ; Altmann, Karl-Heinz ; Gaugaz, Fabienne Z ; Gaugaz, Fabienne Z ; Schiess, Raphael ; Schiess, Raphael Appendino, Giovanni ; Appendino, Giovanni ; Banfi, Luca ; Banfi, Luca

Molecular diversity, 2011-05, Vol.15 (2), p.383-399 [Peer Reviewed Journal]

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9
High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells
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High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

Pera, Benet ; Calvo-Vidal, M. Nieves ; Ambati, Srikanth ; Jordi, Michel ; Kahn, Alissa ; Díaz, J. Fernando ; Fang, Weishuo ; Altmann, Karl-Heinz ; Cerchietti, Leandro ; Moore, Malcolm A.S

Cancer Letters, 2015, Vol.368 (1), p.97-104 [Peer Reviewed Journal]

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10
Epothilone Analogues with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with Tubulin
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Epothilone Analogues with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with Tubulin

Dietrich, Silvia Anthoine ; Lindauer, Renate ; Stierlin, Claire ; Gertsch, Jürg ; Matesanz, Ruth ; Notararigo, Sara ; Díaz, José Fernando ; Altmann, KarlHeinz

Chemistry : a European journal, 2009-10-05, Vol.15 (39), p.10144-10157 [Peer Reviewed Journal]

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