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Results 1 - 10 of 21  for Great Falls College MSU

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1
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
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A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

Andrea E. Prota ; Katja Bargsten ; J. Fernando Diaz ; May Marsh ; Carmen Cuevas ; Marc Liniger ; Christian Neuhaus ; Jose M. Andreu ; Karl-Heinz Altmann ; Michel O. Steinmetz

Proceedings of the National Academy of Sciences - PNAS, 2014-08-11, Vol.111 (38), p.13817-13821

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2
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
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Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

Prota, Andrea E ; Bargsten, Katja ; Zurwerra, Didier ; Field, Jessica J ; Díaz, José Fernando ; Altmann, Karl-Heinz ; Steinmetz, Michel O

Science (American Association for the Advancement of Science), 2013-02-01, Vol.339 (6119), p.587-590 [Peer Reviewed Journal]

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3
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands
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Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

Balaguer, Francisco de Asís ; Mühlethaler, Tobias ; Estévez-Gallego, Juan ; Calvo, Enrique ; Giménez-Abián, Juan Francisco ; Risinger, April L ; Sorensen, Erik J ; Vanderwal, Christopher D ; Altmann, Karl-Heinz ; Mooberry, Susan L ; Steinmetz, Michel O ; Oliva, María Ángela ; Prota, Andrea E ; Díaz, J Fernando

International journal of molecular sciences, 2019-03-20, Vol.20 (6), p.1392 [Peer Reviewed Journal]

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4
Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives
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Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives

Altmann, Karl-Heinz ; Altmann, Karl-Heinz ; Gaugaz, Fabienne Z ; Gaugaz, Fabienne Z ; Schiess, Raphael ; Schiess, Raphael Appendino, Giovanni ; Appendino, Giovanni ; Banfi, Luca ; Banfi, Luca

Molecular diversity, 2011-05, Vol.15 (2), p.383-399 [Peer Reviewed Journal]

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5
High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells
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High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

Pera, Benet ; Calvo-Vidal, M. Nieves ; Ambati, Srikanth ; Jordi, Michel ; Kahn, Alissa ; Díaz, J. Fernando ; Fang, Weishuo ; Altmann, Karl-Heinz ; Cerchietti, Leandro ; Moore, Malcolm A.S

Cancer Letters, 2015, Vol.368 (1), p.97-104 [Peer Reviewed Journal]

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6
Epothilone Analogues with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with Tubulin
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Epothilone Analogues with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with Tubulin

Dietrich, Silvia Anthoine ; Lindauer, Renate ; Stierlin, Claire ; Gertsch, Jürg ; Matesanz, Ruth ; Notararigo, Sara ; Díaz, José Fernando ; Altmann, KarlHeinz

Chemistry : a European journal, 2009-10-05, Vol.15 (39), p.10144-10157 [Peer Reviewed Journal]

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7
Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A
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Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A

Prota, Andrea E ; Bargsten, Katja ; Northcote, Peter T ; Marsh, May ; Altmann, Karl-Heinz ; Miller, John H ; Díaz, José Fernando ; Steinmetz, Michel O

Angewandte Chemie (International ed.), 2014-02-03, Vol.53 (6), p.1621-1625 [Peer Reviewed Journal]

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8
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin
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A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Menchon, Grégory ; Prota, Andrea E ; Lucena-Agell, Daniel ; Bucher, Pascal ; Jansen, Rolf ; Irschik, Herbert ; Müller, Rolf ; Paterson, Ian ; Díaz, J. Fernando ; Altmann, Karl-Heinz ; Steinmetz, Michel O

Nature communications, 2018-05-29, Vol.9 (1), p.2106-2106 [Peer Reviewed Journal]

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9
The Impact of Cyclopropane Configuration on the Biological Activity of Cyclopropyl‐Epothilones
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The Impact of Cyclopropane Configuration on the Biological Activity of Cyclopropyl‐Epothilones

Gaugaz, Fabienne Z ; Redondo‐Horcajo, Mariano ; Barasoain, Isabel ; Díaz, J. Fernando ; Cobos‐Correa, Amanda ; Kaufmann, Markus ; Altmann, KarlHeinz

ChemMedChem, 2014-10, Vol.9 (10), p.2227-2232 [Peer Reviewed Journal]

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10
Differential Effects of Natural Product Microtubule Stabilizers on Microtubule Assembly: Single Agent and Combination Studies with Taxol, Epothilone B, and Discodermolide
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Differential Effects of Natural Product Microtubule Stabilizers on Microtubule Assembly: Single Agent and Combination Studies with Taxol, Epothilone B, and Discodermolide

Gertsch, Jürg ; Meier, Sarah ; Müller, Martin ; Altmann, KarlHeinz

Chembiochem : a European journal of chemical biology, 2009-01-05, Vol.10 (1), p.166-175 [Peer Reviewed Journal]

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