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CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.

Westra, Edze R ; van Erp, Paul B G ; Künne, Tim ; Wong, Shi Pey ; Staals, Raymond H J ; Seegers, Christel L C ; Bollen, Sander ; Jore, Matthijs M ; Semenova, Ekaterina ; Severinov, Konstantin ; de Vos, Willem M ; Dame, Remus T ; de Vries, Renko ; Brouns, Stan J J ; van Der Oost, John Westra, Edze R (correspondence author) ; Westra, Edze R (record owner)

Molecular cell, June 8, 2012, Vol.46(5), pp.595-605 [Peer Reviewed Journal]

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2
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Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.

Redding, Sy ; Sternberg, Samuel H ; Marshall, Myles ; Gibb, Bryan ; Bhat, Prashant ; Guegler, Chantal K ; Wiedenheft, Blake ; Doudna, Jennifer A ; Greene, Eric C Redding, Sy (correspondence author) ; Redding, Sy (record owner)

Cell, November 5, 2015, Vol.163(4), pp.854-865 [Peer Reviewed Journal]

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3
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Spacer-length DNA intermediates are associated with Cas1 in cells undergoing primed CRISPR adaptation.

Musharova, Olga ; Klimuk, Evgeny ; Datsenko, Kirill A ; Metlitskaya, Anastasia ; Logacheva, Maria ; Semenova, Ekaterina ; Severinov, Konstantin ; Savitskaya, Ekaterina Musharova, Olga (correspondence author) ; Musharova, Olga (record owner)

Nucleic acids research, April 7, 2017, Vol.45(6), pp.3297-3307 [Peer Reviewed Journal]

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4
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Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS.

Majsec, Kristina ; Bolt, Edward L ; Ivančić-Baće, Ivana Majsec, Kristina (correspondence author) ; Majsec, Kristina (record owner)

BMC microbiology, March 8, 2016, Vol.16, p.28 [Peer Reviewed Journal]

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5
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Easy regulation of metabolic flux in Escherichia coli using an endogenous type I-E CRISPR-Cas system.

Chang, Yizhao ; Su, Tianyuan ; Qi, Qingsheng ; Liang, Quanfeng Chang, Yizhao (correspondence author) ; Chang, Yizhao (record owner)

Microbial cell factories, November 15, 2016, Vol.15(1), p.195 [Peer Reviewed Journal]

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6
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Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity.

Xue, Chaoyou ; Whitis, Natalie R ; Sashital, Dipali G Xue, Chaoyou (correspondence author) ; Xue, Chaoyou (record owner)

Molecular cell, November 17, 2016, Vol.64(4), pp.826-834 [Peer Reviewed Journal]

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7
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Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.

Hayes, Robert P ; Xiao, Yibei ; Ding, Fran ; van Erp, Paul B G ; Rajashankar, Kanagalaghatta ; Bailey, Scott ; Wiedenheft, Blake ; Ke, Ailong Hayes, Robert P (correspondence author) ; Hayes, Robert P (record owner)

Nature, February 25, 2016, Vol.530(7591), pp.499-503 [Peer Reviewed Journal]

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8
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CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference.

Hochstrasser, Megan L ; Taylor, David W ; Bhat, Prashant ; Guegler, Chantal K ; Sternberg, Samuel H ; Nogales, Eva ; Doudna, Jennifer A Hochstrasser, Megan L (correspondence author) ; Hochstrasser, Megan L (record owner)

Proceedings of the National Academy of Sciences of the United States of America, May 6, 2014, Vol.111(18), pp.6618-6623 [Peer Reviewed Journal]

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9
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Cas3 stimulates runaway replication of a ColE1 plasmid in Escherichia coli and antagonises RNaseHI.

Ivančić-Baće, Ivana ; Radovčić, Marin ; Bočkor, Luka ; Howard, Jamieson L ; Bolt, Edward L Ivančić-Baće, Ivana (correspondence author) ; Ivančić-Baće, Ivana (record owner)

RNA biology, May 2013, Vol.10(5), pp.770-778 [Peer Reviewed Journal]

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10
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Cas3-Derived Target DNA Degradation Fragments Fuel Primed CRISPR Adaptation.

Künne, Tim ; Kieper, Sebastian N ; Bannenberg, Jasper W ; Vogel, Anne I M ; Miellet, Willem R ; Klein, Misha ; Depken, Martin ; Suarez-Diez, Maria ; Brouns, Stan J J Künne, Tim (correspondence author) ; Künne, Tim (record owner)

Molecular cell, September 1, 2016, Vol.63(5), pp.852-864 [Peer Reviewed Journal]

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