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1
Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
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Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

Roberts, Andrew W ; Seymour, John F ; Brown, Jennifer R ; Wierda, William G ; Kipps, Thomas J ; Khaw, Seong Lin ; Carney, Dennis A ; He, Simon Z ; Huang, David C.S ; Xiong, Hao ; Cui, Yue ; Busman, Todd A ; McKeegan, Evelyn M ; Krivoshik, Andrew P ; Enschede, Sari H ; Humerickhouse, Rod

Journal of clinical oncology, 2012-02-10, Vol.30 (5), p.488-496 [Peer Reviewed Journal]

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2
Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy
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Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

Min H. Kang ; C. Patrick Reynolds

Clinical Cancer Research, 2009-02-15, Vol.15 (4), p.1126-1132 [Peer Reviewed Journal]

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3
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Souers, Andrew J ; Leverson, Joel D ; Boghaert, Erwin R ; Ackler, Scott L ; Catron, Nathaniel D ; Chen, Jun ; Dayton, Brian D ; Ding, Hong ; Enschede, Sari H ; Fairbrother, Wayne J ; Huang, David C S ; Hymowitz, Sarah G ; Jin, Sha ; Khaw, Seong Lin ; Kovar, Peter J ; Lam, Lloyd T ; Lee, Jackie ; Maecker, Heather L ; Marsh, Kennan C ; Mason, Kylie D ; Mitten, Michael J ; Nimmer, Paul M ; Oleksijew, Anatol ; Park, Chang H ; Park, Cheol-Min ; Phillips, Darren C ; Roberts, Andrew W ; Sampath, Deepak ; Seymour, John F ; Smith, Morey L ; Sullivan, Gerard M ; Tahir, Stephen K ; Tse, Chris ; Wendt, Michael D ; Xiao, Yu ; Xue, John C ; Zhang, Haichao ; Humerickhouse, Rod A ; Rosenberg, Saul H ; Elmore, Steven W

Nature medicine, 2013-01-06, Vol.19 (2), p.202-208 [Peer Reviewed Journal]

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4
AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer
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AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Cross, Darren A.E ; Ashton, Susan E ; Ghiorghiu, Serban ; Eberlein, Cath ; Nebhan, Caroline A ; Spitzler, Paula J ; Orme, Jonathon P ; Finlay, M. Raymond V ; Ward, Richard A ; Mellor, Martine J ; Hughes, Gareth ; Rahi, Amar ; Jacobs, Vivien N ; Brewer, Monica Red ; Ichihara, Eiki ; Sun, Jing ; Jin, Hailing ; Ballard, Peter ; Al-Kadhimi, Katherine ; Rowlinson, Rachel ; Klinowska, Teresa ; Richmond, Graham H.P ; Cantarini, Mireille ; Kim, Dong-Wan ; Ranson, Malcolm R ; Pao, William

Cancer discovery, 2014-09, Vol.4 (9), p.1046-1061

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5
Simplified Quantification of Pittsburgh Compound B Amyloid Imaging PET Studies: A Comparative Analysis
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Simplified Quantification of Pittsburgh Compound B Amyloid Imaging PET Studies: A Comparative Analysis

Lopresti, Brian J ; Klunk, William E ; Mathis, Chester A ; Hoge, Jessica A ; Ziolko, Scott K ; Lu, Xueling ; Meltzer, Carolyn C ; Schimmel, Kurt ; Tsopelas, Nicholas D ; DeKosky, Steven T ; Price, Julie C

The Journal of Nuclear Medicine, 2005-12-01, Vol.46 (12), p.1959-1972 [Peer Reviewed Journal]

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6
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer
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A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

Hochwald, Steven N ; Nyberg, Carl ; Zheng, Min ; Zheng, Donghang ; Wood, Cheng ; Massoll, Nicole A ; Magis, Andrew ; Ostrov, David ; Cance, William G ; Golubovskaya, Vita M

Cell cycle (Georgetown, Tex.), 2014-10-28, Vol.8 (15), p.2435-2443 [Peer Reviewed Journal]

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7
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, Jianhui ; Wang, Yingying ; Shao, Lijian ; Laberge, Remi-Martin ; Demaria, Marco ; Campisi, Judith ; Janakiraman, Krishnamurthy ; Sharpless, Norman E ; Ding, Sheng ; Feng, Wei ; Luo, Yi ; Wang, Xiaoyan ; Aykin-Burns, Nukhet ; Krager, Kimberly ; Ponnappan, Usha ; Hauer-Jensen, Martin ; Meng, Aimin ; Zhou, Daohong

Nature medicine, 2015-12-14, Vol.22 (1), p.78-83 [Peer Reviewed Journal]

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8
Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload–Induced Apoptosis in the Heart
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Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload–Induced Apoptosis in the Heart

Kimura, Tomomi E ; Jin, Jiawei ; Zi, Min ; Prehar, Sukhpal ; Liu, Wei ; Oceandy, Delvac ; Abe, Jun-ichi ; Neyses, Ludwig ; Weston, Arthur H ; Cartwright, Elizabeth J ; Wang, Xin

Circulation research, 2010-03-19, Vol.106 (5), p.961-970 [Peer Reviewed Journal]

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9
Diketopyrrolopyrrole–Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy
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Diketopyrrolopyrrole–Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy

Cai, Yu ; Liang, Pingping ; Tang, Qianyun ; Yang, Xiaoyan ; Si, Weili ; Huang, Wei ; Zhang, Qi ; Dong, Xiaochen

ACS nano, 2017-01-24, Vol.11 (1), p.1054-1063 [Peer Reviewed Journal]

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10
Inhibition of Ser/Thr Phosphatases Induces Capacitation-associated Signaling in the Presence of Src Kinase Inhibitors
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Inhibition of Ser/Thr Phosphatases Induces Capacitation-associated Signaling in the Presence of Src Kinase Inhibitors

Dario Krapf ; Enid Arcelay ; Eva V. Wertheimer ; Archana Sanjay ; Stephen H. Pilder ; Ana M. Salicioni ; Pablo E. Visconti

Journal of Biological Chemistry, 2010-03-12, Vol.285 (11), p.7977-7985 [Peer Reviewed Journal]

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