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A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia
A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia
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A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia

Stein, Eytan M ; Walter, Roland B ; Erba, Harry P ; Fathi, Amir T ; Advani, Anjali S ; Lancet, Jeffrey E ; Ravandi, Farhad ; Kovacsovics, Tibor ; DeAngelo, Daniel J ; Bixby, Dale ; Faderl, Stefan ; Jillella, Anand P ; Ho, Phoenix A ; O'Meara, Megan M ; Zhao, Baiteng ; Biddle-Snead, Charles ; Stein, Anthony S

Blood, 2018-01-25, Vol.131 (4), p.387-396 [Peer Reviewed Journal]

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2
DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1
DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1
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DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

Ogitani, Yusuke ; Aida, Tetsuo ; Hagihara, Katsunobu ; Yamaguchi, Junko ; Ishii, Chiaki ; Harada, Naoya ; Soma, Masako ; Okamoto, Hiromi ; Oitate, Masataka ; Arakawa, Shingo ; Hirai, Takehiro ; Atsumi, Ryo ; Nakada, Takashi ; Hayakawa, Ichiro ; Abe, Yuki ; Agatsuma, Toshinori

Clinical cancer research, 2016-10-15, Vol.22 (20), p.5097-5108 [Peer Reviewed Journal]

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3
Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index
Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index
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Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

Lyon, Robert P ; Bovee, Tim D ; Doronina, Svetlana O ; Burke, Patrick J ; Hunter, Joshua H ; Neff-LaFord, Haley D ; Jonas, Mechthild ; Anderson, Martha E ; Setter, Jocelyn R ; Senter, Peter D

Nature biotechnology, 2015-07, Vol.33 (7), p.733-735 [Peer Reviewed Journal]

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4
Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer
Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer
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Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer

Cornelissen, Bart ; Able, Sarah ; Kartsonaki, Christiana ; Kersemans, Veerle ; Allen, P Danny ; Cavallo, Federica ; Cazier, Jean-Baptiste ; Iezzi, Manuela ; Knight, James ; Muschel, Ruth ; Smart, Sean ; Vallis, Katherine A

The Journal of nuclear medicine (1978), 2014-12, Vol.55 (12), p.2026-2031 [Peer Reviewed Journal]

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5
Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin
Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin
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Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin

Horwitz, Steven M ; Advani, Ranjana H ; Bartlett, Nancy L ; Jacobsen, Eric D ; Sharman, Jeff P ; O'Connor, Owen A ; Siddiqi, Tanya ; Kennedy, Dana A ; Oki, Yasuhiro

Blood, 2014-05-15, Vol.123 (20), p.3095-3100 [Peer Reviewed Journal]

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6
A bioorthogonal system reveals antitumour immune function of pyroptosis
A bioorthogonal system reveals antitumour immune function of pyroptosis
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A bioorthogonal system reveals antitumour immune function of pyroptosis

Wang, Qinyang ; Wang, Yupeng ; Ding, Jingjin ; Wang, Chunhong ; Zhou, Xuehan ; Gao, Wenqing ; Huang, Huanwei ; Shao, Feng ; Liu, Zhibo

Nature (London), 2020-03, Vol.579 (7799), p.421-426 [Peer Reviewed Journal]

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7
Absorption, distribution, metabolism, and excretion considerations for the development of antibody-drug conjugates
Absorption, distribution, metabolism, and excretion considerations for the development of antibody-drug conjugates
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Absorption, distribution, metabolism, and excretion considerations for the development of antibody-drug conjugates

Han, Tae H ; Zhao, Baiteng

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1914-1920 [Peer Reviewed Journal]

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8
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
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Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Rossin, Raffaella ; Versteegen, Ron M ; Wu, Jeremy ; Khasanov, Alisher ; Wessels, H.J ; Steenbergen, E.J ; Hudson, Peter J ; Robillard, Marc S

Nature communications, 2018, Vol.9 (1), p.1484-1484 [Peer Reviewed Journal]

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9
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design
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Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Dorywalska, Magdalena ; Dushin, Russell ; Moine, Ludivine ; Farias, Santiago E ; Zhou, Dahui ; Navaratnam, Thayalan ; Lui, Victor ; Hasa-Moreno, Adela ; Casas, Meritxell Galindo ; Tran, Thomas-Toan ; Delaria, Kathy ; Liu, Shu-Hui ; Foletti, Davide ; O'Donnell, Christopher J ; Pons, Jaume ; Shelton, David L ; Rajpal, Arvind ; Strop, Pavel

Molecular cancer therapeutics, 2016-05, Vol.15 (5), p.958-970 [Peer Reviewed Journal]

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10
Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas
Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas
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Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

Younes, Anas ; Bartlett, Nancy L ; Leonard, John P ; Kennedy, Dana A ; Lynch, Carmel M ; Sievers, Eric L ; Forero-Torres, Andres

The New England journal of medicine, 2010-11-04, Vol.363 (19), p.1812-1821 [Peer Reviewed Journal]

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