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Lipid droplet‐mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib
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Lipid droplet‐mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib

Englinger, Bernhard ; Laemmerer, Anna ; Moser, Patrick ; Kallus, Sebastian ; Röhrl, Clemens ; Pirker, Christine ; Baier, Dina ; Mohr, Thomas ; Niederstaetter, Laura ; Meier‐Menches, Samuel M ; Gerner, Christopher ; Gabler, Lisa ; Gojo, Johannes ; Timelthaler, Gerald ; Senkiv, Julia ; Jäger, Walter ; Kowol, Christian R ; Heffeter, Petra ; Berger, Walter

International journal of cancer, 2020-09-15, Vol.147 (6), p.1680-1693 [Peer Reviewed Journal]

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Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074
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Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Laemmerer, Anna ; Moser, Patrick ; Gabler, Lisa ; Groza, Diana ; Kowol, Christian R ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter

Cells (Basel, Switzerland), 2018-12-08, Vol.7 (12), p.259 [Peer Reviewed Journal]

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Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; van Schoonhoven, Sushilla ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; Jäger, Walter ; Kowol, Christian R ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter

Journal of experimental & clinical cancer research, 2017-09-07, Vol.36 (1), p.122-122

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Additional file 5: Figure S3. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Additional file 5: Figure S3. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; Sushilla Van Schoonhoven ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; JäGer, Walter ; Kowol, Christian ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter 2017

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Additional file 2: Figure S1. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Additional file 2: Figure S1. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; Sushilla Van Schoonhoven ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; JäGer, Walter ; Kowol, Christian ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter 2017

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Additional file 4: Figure S2. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Additional file 4: Figure S2. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; Sushilla Van Schoonhoven ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; JäGer, Walter ; Kowol, Christian ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter 2017

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7
Additional file 3: Table S2. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Additional file 3: Table S2. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; Sushilla Van Schoonhoven ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; JäGer, Walter ; Kowol, Christian ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter 2017

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8
Additional file 2: Figure S1. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Additional file 2: Figure S1. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; Sushilla Van Schoonhoven ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; JäGer, Walter ; Kowol, Christian ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter 2017

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9
Additional file 4: Figure S2. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Additional file 4: Figure S2. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; Sushilla Van Schoonhoven ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; JäGer, Walter ; Kowol, Christian ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter 2017

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10
Additional file 1: Table S1. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
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Datasets
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Additional file 1: Table S1. of Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

Englinger, Bernhard ; Kallus, Sebastian ; Senkiv, Julia ; Heilos, Daniela ; Gabler, Lisa ; Sushilla Van Schoonhoven ; Terenzi, Alessio ; Moser, Patrick ; Pirker, Christine ; Timelthaler, Gerald ; JäGer, Walter ; Kowol, Christian ; Heffeter, Petra ; Grusch, Michael ; Berger, Walter 2017

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