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Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.

Ceribelli, Michele ; Kelly, Priscilla N ; Shaffer, Arthur L ; Wright, George W ; Xiao, Wenming ; Yang, Yibin ; Mathews Griner, Lesley A ; Guha, Rajarshi ; Shinn, Paul ; Keller, Jonathan M ; Liu, Dongbo ; Patel, Paresma R ; Ferrer, Marc ; Joshi, Shivangi ; Nerle, Sujata ; Sandy, Peter ; Normant, Emmanuel ; Thomas, Craig J ; Staudt, Louis M Ceribelli, Michele (correspondence author) ; Ceribelli, Michele (record owner)

Proceedings of the National Academy of Sciences of the United States of America, August 5, 2014, Vol.111(31), pp.11365-11370 [Peer Reviewed Journal]

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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.

Zhang, Meili ; Mathews Griner, Lesley A ; Ju, Wei ; Duveau, Damien Y ; Guha, Rajarshi ; Petrus, Michael N ; Wen, Bernard ; Maeda, Michiyuki ; Shinn, Paul ; Ferrer, Marc ; Conlon, Kevin D ; Bamford, Richard N ; O'Shea, John J ; Thomas, Craig J ; Waldmann, Thomas A Zhang, Meili (correspondence author) ; Zhang, Meili (record owner)

Proceedings of the National Academy of Sciences of the United States of America, October 6, 2015, Vol.112(40), pp.12480-12485 [Peer Reviewed Journal]

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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Mathews Griner, Lesley A ; Guha, Rajarshi ; Shinn, Paul ; Young, Ryan M ; Keller, Jonathan M ; Liu, Dongbo ; Goldlust, Ian S ; Yasgar, Adam ; Mcknight, Crystal ; Boxer, Matthew B ; Duveau, Damien Y ; Jiang, Jian-Kang ; Michael, Sam ; Mierzwa, Tim ; Huang, Wenwei ; Walsh, Martin J ; Mott, Bryan T ; Patel, Paresma ; Leister, William ; Maloney, David J ; Leclair, Christopher A ; Rai, Ganesha ; Jadhav, Ajit ; Peyser, Brian D ; Austin, Christopher P ; Martin, Scott E ; Simeonov, Anton ; Ferrer, Marc ; Staudt, Louis M ; Thomas, Craig J Mathews Griner, Lesley A (correspondence author) ; Mathews Griner, Lesley A (record owner)

Proceedings of the National Academy of Sciences of the United States of America, February 11, 2014, Vol.111(6), pp.2349-2354 [Peer Reviewed Journal]

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Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Huang, Ruili ; Xia, Menghang ; Cho, Ming-Hsuang ; Sakamuru, Srilatha ; Shinn, Paul ; Houck, Keith A ; Dix, David J ; Judson, Richard S ; Witt, Kristine L ; Kavlock, Robert J ; Tice, Raymond R ; Austin, Christopher P Huang, Ruili (correspondence author) ; Huang, Ruili (record owner)

Environmental health perspectives, August 2011, Vol.119(8), pp.1142-1148 [Peer Reviewed Journal]

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Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens

Wei Sun ; Yoon-Dong Park ; Janyce A Sugui ; Annette Fothergill ; Noel Southall ; Paul Shinn ; John C Mckew ; Kyung J Kwon-Chung ; Wei Zheng ; Peter R Williamson

PLoS ONE, 01 January 2013, Vol.8(8), p.e70506 [Peer Reviewed Journal]

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Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies
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Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies

Antignani, Antonella ; Pasetto, Matteo ; Choo, Chris ; Angelus, Evan ; Mathews, Lesley ; Guha, Rajarshi ; Shinn, Paul ; Ferrer, Marc ; Thomas, Craig J. ; Pastan, Ira ; Fitzgerald, David J.

Cancer Research, 10/01/2014, Vol.74(19 Supplement), pp.2907-2907 [Peer Reviewed Journal]

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Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.

Lee, Jonathan A ; Shinn, Paul ; Jaken, Susan ; Oliver, Sarah ; Willard, Francis S ; Heidler, Steven ; Peery, Robert B ; Oler, Jennifer ; Chu, Shaoyou ; Southall, Noel ; Dexheimer, Thomas S ; Smallwood, Jeffrey ; Huang, Ruili ; Guha, Rajarshi ; Jadhav, Ajit ; Cox, Karen ; Austin, Christopher P ; Simeonov, Anton ; Sittampalam, G Sitta ; Husain, Saba ; Franklin, Natalie ; Wild, David J ; Yang, Jeremy J ; Sutherland, Jeffrey J ; Thomas, Craig J Lee, Jonathan A (correspondence author) ; Lee, Jonathan A (record owner)

PloS one, 2015, Vol.10(7), p.e0130796 [Peer Reviewed Journal]

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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

Coussens, Nathan P ; Kales, Stephen C ; Henderson, Mark J ; Lee, Olivia W ; Horiuchi, Kurumi Y ; Wang, Yuren ; Chen, Qing ; Kuznetsova, Ekaterina ; Wu, Jianghong ; Chakka, Sirisha ; Cheff, Dorian M ; Cheng, Ken Chih-Chien ; Shinn, Paul ; Brimacombe, Kyle R ; Shen, Min ; Simeonov, Anton ; Lal-Nag, Madhu ; Ma, Haiching ; Jadhav, Ajit ; Hall Coussens, Nathan P (correspondence author) ; Coussens, Nathan P (record owner)

The Journal of biological chemistry, August 31, 2018, Vol.293(35), pp.13750-13765 [Peer Reviewed Journal]

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Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.

Davis, Mindy I ; Pragani, Rajan ; Fox, Jennifer T ; Shen, Min ; Parmar, Kalindi ; Gaudiano, Emily F ; Liu, Li ; Tanega, Cordelle ; Mcgee, Lauren ; Hall, Matthew D ; Mcknight, Crystal ; Shinn, Paul ; Nelson, Henrike ; Chattopadhyay, Debasish ; D'Andrea, Alan D ; Auld, Douglas S ; Delucas, Larry J ; Li, Zhuyin ; Boxer Davis, Mindy I (correspondence author) ; Davis, Mindy I (record owner)

The Journal of biological chemistry, November 18, 2016, Vol.291(47), pp.24628-24640 [Peer Reviewed Journal]

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Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors

Capuzzi, Stephen J ; Sun, Wei ; Muratov, Eugene N ; Martínez-Romero, Carles ; He, Shihua ; Zhu, Wenjun ; Li, Hao ; Tawa, Gregory ; Fisher, Ethan G ; Xu, Miao ; Shinn, Paul ; Qiu, Xiangguo ; García-Sastre, Adolfo ; Zheng, Wei ; Tropsha, Alexander

Journal of Medicinal Chemistry, 26 April 2018, Vol.61(8), pp.3582-3594 [Peer Reviewed Journal]

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